Day 1. Depart Osh and drive to Murghab in Tajikistan. Short stop in Karakul to stretch the legs on a hike along the biggest lake in Tajikistan. Overnight in a homestay in Murghab.
Day 2. Drive towards the Tajik Wakhan. Short detour to Bulunkul to see the lakes and to eat the famous fried 'marinka'. Continue driving to the Wakhan via the Khargush pass (4344 m) along the Pamir river. If time permits, 2-3 hike to the viewpoint of the pass. Overnight in a homestay in Langar.
Day 3. Early morning 2-2.5 hours hike to the petroglyphs above the Langar village. Drive to Khorog. On the way stops to see the Museum and the Solar Calendar of Sufi Muborak, ruins of 2 castles, Bibi-Fatima hot spring. Overnight in a homestay in Khorog.
Day 4. Morning Khorog City Tour: Botanical Garden, Khorog Jamaatkhana and Ismaili Center, City Park. After lunch driving to Kalai-Khumb. Overnight in a homestay in Kalai-Khumb.
Day 5. Drive to Dushanbe. A few stops to see the Khulbuk fortress and Hamadoni Museum.